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Sildenafil v/s Tadalafil: Which one is Better for ED?

The duration of the two substances is the key distinction between them. Tadalafil has full of 36 hours, which implies it may cure erectile dysfunction at any moment throughout that time period. While competitor Sildenafil usually only lasts 4 to 6 hours. As a result, many people choose Tadalafil since it helps them to have satisfying sex.

Viagra(Sildenafil) v/s Cialis(Tadalafil): How are they different?

The two most often prescribed phosphodiesterase 5 inhibitors for treating ED are tadalafil and sildenafil.

  • Another significant advantage of Tadalafil is that it may be taken on an empty stomach or with a meal, with no influence on the drug's potency or duration of action. It is unnecessary to take Viagra (sildenafil) with food.
  • In reality, taking Viagra shortly after a big meal, particularly one high in fat, might cause the drug's absorption to be delayed, making it less potent.
  • Tadalafil and sildenafil proved to have comparable efficacies and aggregate adverse reaction rates in the meta-analysis.
  • Tadalafil, on the other hand, considerably enhanced psychological effects when compared to sildenafil.
  • Both patients and their spouses favored tadalafil over sildenafil, and no substantial change in compliance and perseverance rates was detected between the two drugs.
  • Furthermore, tadalafil had a greater incidence of myalgia and back discomfort and a lower rate of flushing than sildenafil.
  • Tadalafil has equal effectiveness and safety to sildenafil and boosts patients' sexual confidence greatly.
  • Cialis is preferred over sildenafil by patients and their spouses. Therefore, tadalafil may be a preferable alternative for treating ED. 
  • Regarding the treatment of erectile dysfunction, there is no "best" medication. Cialis and Viagra have relatively similar effects, yet each has its unique share of benefits:
  • If you require a "weekend" erectile dysfunction medicine that lasts a long time and allows you to have sex whenever you desire without having to prepare ahead of time, Cialis is definitely a better option for you.
  • If you want a narrower erectile dysfunction medicine that allows you to have sex for a single night without leaving your system too long, Viagra's brief duration of action and ease are likely to be attractive to you.

Erectile dysfunction (ED) is described as the difficulty to develop and maintain an adequate erection to allow for satisfying sexual intercourse. ED is among the most frequent sexual dysfunctions, with an estimated 5-20% of men worldwide suffering from mild to severe ED.


What is Tadalafil?

Cialis (tadalafil) is the one drug in its class that cures simultaneous erectile dysfunction and symptoms of an enlarged prostate. You may also take it on a routine basis, allowing you more flexibility.


  • A treatment option for erectile dysfunction.
  • This allows you to be more flexible about the time of sex.
  • Longer lasting than Viagra (sildenafil).


  • Not to be used if you have had a stroke or heart failure within the last six months.
  • If you have recently used nitrates such as Isordil, Imdur, or nitroglycerin.
  • Older may have higher adverse effects; take this drug with caution.
  • Riociguat is used to treat pulmonary arterial hypertension.
  • Are not in good enough condition to engage in sexual activities.

What is Sildenafil?

Viagra (sildenafil) is an effective erectile dysfunction treatment. Because Viagra (sildenafil) must be taken around 60 minutes prior to engaging in sexual activity, the lack of excitement may not function for some individuals.


  • Medicine for treating erectile dysfunction.
  • Not need to be taken on a regular basis - consume it only if necessary.


  • you should not take this medication If you have had a stroke.
  • If you have recently used nitrate medications.
  • Elderly patients may be more susceptible to harmful effects; use with care.
  • Riociguat is used to treat pulmonary arterial hypertension.
  • Should be taken around one hour before sexual activity.
  • Are not in sufficient health to engage in sexual activity.

Which Medication Is Safer, Cialis or Viagra?

Cialis and Viagra together have been shown to be relatively safe. They may, however, interact with other prescriptions, vitamins, and recreational substances, as can all prescription pharmaceuticals.

Cialis, Viagra, and other PDE5 inhibitors may be dangerous when combined with certain blood pressure drugs, as well as medicines that are used to relieve symptoms or after some kinds of heart surgery.

How do Sildenafil and Tadalafil function?

Similar to Sildenafil, Tadalafil is a PDE-5 inhibitor. When stimulated, the PDE-5 family of drugs maintains relaxed muscle tone while enhancing blood flow to the penis, hence facilitating erection development.

Which is more effective, tadalafil or sildenafil?

Compared to sildenafil, tadalafil has a higher half-life. Tadalafil often works 10 to 20 minutes quicker than sildenafil. Sildenafil's effect time is up to four hours, whilst tadalafil's is up to thirty-six hours. Sildenafil requires 30 to 60 minutes to take action, whereas tadalafil needs 20 to 30 minutes.


  • Risk of a stroke 
  • Hypertension
  • Prolonged erection
  • Vision changes
  • Hearing loss
  • Interactions with other medications

Are There Any Side Effects?

Because Cialis will remain in your system for a long time than Viagra, it's crucial to understand the potential adverse effects as they may influence your choice. The longer it stays in your circulation, the more likely you are to have negative effects.

Other potential adverse effects include:

  • Headaches
  • Indigestion
  • Flushing
  • Nosebleeds
  • Sleeping problems
  • Sleeping problems
  • Infection of the lungs
  • Nausea
  • Vomiting
  • Vision blur
  • Sore throat caused by Bronchitis

While they are uncommon, it is vital to remember that they have been possible:

  • Low blood pressure,
  • dizziness,
  • Shortness of breath.
  • Vision issues
  • Hearing issues
  • Heart issues

What are the Recommended Dosages?

Tadalafil: The suggested beginning dosage for most people is 10 mg per day administered before sexual activity. The dosage may be raised to 20 mg or lowered to 5 mg each day depending on your body's reaction. Those with renal or liver disease may need extra modifications.

Sildenafil: Take between 25 and 100 mg of this medication an hour ahead of performing a sexual act. The maximum daily dose is 100 mg. Sildenafil should indeed be consumed on an empty stomach to have the best effect. Patients over the age of 65 are normally advised to begin with 25mg, but the dose may be modified as required.

Is it safe to consume tadalafil with sildenafil together?

Tadalafil and sildenafil should not be taken simultaneously or on the same date. Multiple ED drugs taken at once or on the same day may cause unfavorable and sometimes serious adverse effects. 

Which has a higher rate of success?

In clinical studies, both tadalafil and sildenafil have had equal success rates, with both showing efficacies in more than 80% of people who take either medicine.

Which medication has fewer negative effects, sildenafil or tadalafil?

Tadalafil and sildenafil have comparable side-effect ratings, however, tadalafil's negative effects may remain longer because of its broader duration of action. Headache is a typical adverse effect of both.


Which is better, sildenafil or tadalafil?

On principle, tadalafil is superior to sildenafil since it has many benefits, the most notable of which is its long period of action. Additionally, it operates faster than sildenafil and has fewer adverse effects.